Institut für Verfahrenstechnik, Umwelttechnik und Techn. Biowissenschaften
> Zum Inhalt

Analyzing CFD Simulation Outputs on Physiologic Effects And Process Performance

 

Wir bitten um Verständnis, dass die Informationen über dieses Projekt derzeit nur in englischer Sprache verfügbar sind

Problem Statement

 

  • Scale up of processes is a difficult task due to inhomogeneities which are present in large scale reactors.
  • Cells undergo dynamic gradients in large scale, leading to different metabolic responses than in small scale.
  • Process performance in large scale is therefore different than in small scale.
  • Process development strategies need to take those scale up effects into account and need to anticipate and ideally compensate those effects.

Goal

  • Derive a methodological workflow to quickly assess if a CFD inhomogeneity pattern actually has an impact on physiology and process performance
  • Provide novel Feeding strategies to compensate scale up effects 

Unique position at VUT

  • Pilot scale reactors of 60 L and 20 L are available at Vienna University of Technology (VUT) for which CFD simulations exist an can be used as scale down reactors.
  • Those reactors can be run at suboptimal conditions to mimic gradients as extracted from CFD simulations of large scale reactors.
  • VUT as distinct knowledge in physiological feeding strategies, such as constant or dynamic specific uptake rates.

 

 

Research hypothesis

  • With the scale down reactors with existing CFD simulations, effects of inhomogeneities in large scale reactors can be quickly assessed.
  • Novel physiological feeding strategies can overcome impacts of inhomogeneities and therefore allow compensation scale up effects.

 

Contact:

Univ.Prof. Dipl.-Ing. Dr.techn. Christoph Herwig

Collaborators:

Danish research consortium

Consortium Lead, DTU, Denmark, Prof. Krist Gernaey

Dr. Jens Fricke