Wir bitten um Verständnis, dass die Informationen über dieses Projekt derzeit nur in englischer Sprache verfügbar sind.
Goals
- Bioprocess development is often excessively long and still owing a very high failure rate. Target oriented bioprocess development
- Develop a transferable workflow including mechanistic model calibration, parameter space reduction and state estimation
- Generation of adaptive, self-calibrating models with platform applicability.
Approach
- Use of mechanistic modelling workflows with historical process development data to screen models and develop initial workflow
- MVDA techniques to perform iterative, in-silico and experimental validation of the workflow.
- Set up and testing of adaptive workflows for platform application in different expression systems.
- Finally, a real-time, adaptive workflow with tech transfer to accelerate process development in Industry
Novelty
- Adaptive model based tools for accelerating bioprocess development, monitoring and control
- Transferable workflows for systematic development
- Verified on industrial relevant processes in a real-time environment
Project overview (click to download)
Funding
This project is funded by the Austrian Research Promotion Agency (FFG) as part of the programme “BRIDGE”.
Contact:
Univ. Prof. Dipl.-Ing. Dr. techn. Christoph Herwig