Goals

• Bioprocess development is often excessively long and still owing a very high failure rate. Target oriented bioprocess development
• Develop a transferable workflow including mechanistic model calibration, parameter space reduction and state estimation
• Generation of adaptive, self-calibrating models with  platform applicability.

Approach

• Use of mechanistic modelling workflows with historical process development data to screen models and develop initial workflow
• MVDA techniques to perform iterative, in-silico and experimental validation of the workflow.
• Set up and testing of adaptive workflows for platform application in different expression systems.
• Finally, a real-time, adaptive workflow with tech transfer to accelerate process development in Industry

Novelty

• Adaptive model based tools for accelerating bioprocess development, monitoring and control
• Transferable workflows for systematic development
• Verified on industrial relevant processes in a real-time environment