Institut für Verfahrenstechnik, Umwelttechnik und Techn. Biowissenschaften
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Wir bitten um Verständnis, dass die Informationen über dieses Projekt derzeit nur in englischer Sprache verfügbar sind.

Goals

  • Bioprocess development is often excessively long and still owing a very high failure rate. Target oriented bioprocess development
  • Develop a transferable workflow including mechanistic model calibration, parameter space reduction and state estimation
  • Generation of adaptive, self-calibrating models with  platform applicability.

Approach

  • Use of mechanistic modelling workflows with historical process development data to screen models and develop initial workflow
  • MVDA techniques to perform iterative, in-silico and experimental validation of the workflow.
  • Set up and testing of adaptive workflows for platform application in different expression systems.
  • Finally, a real-time, adaptive workflow with tech transfer to accelerate process development in Industry

Novelty

  • Adaptive model based tools for accelerating bioprocess development, monitoring and control
  • Transferable workflows for systematic development
  • Verified on industrial relevant processes in a real-time environment

 

 

Project overview (click to download)

Funding

This project is funded by the Austrian Research Promotion Agency (FFG) as part of the programme “BRIDGE”.

Contact:

Univ. Prof. Dipl.-Ing. Dr. techn. Christoph Herwig