Institut für Verfahrenstechnik, Umwelttechnik und Techn. Biowissenschaften
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Sustainable Bioprocess Solutions - Publications

 

For applications and general inquiries, please contact:

stefan.pfluegl@tuwien.ac.at

Publications

2021

Neuendorf C. S., Vignolle G. A., Derntl C., Tomin T., Novak K., Mach R. L., Birner-Grünberger R., Pflügl S. A quantitative metabolic analysis reveals Acetobacterium woodii as a flexible and robust host for formate-based bioproduction. Metabolic Engineering, 2021, 68.

https://doi.org/10.1016/j.ymben.2021.09.004  pdf

Boecker S., Harder B.-J., Kutscha R., Pflügl S., Klamt S. Increasing ATP turnover boosts productivity of 2,3-butanediol synthesis in Escherichia coli. Microbial Cell Factories, 2021, 20(1). 

https://doi.org/10.1186/s12934-021-01554-x  pdf

Mainka T., Weirathmüller D., Herwig C., Pflügl S. Potential applications of halophilic microorganisms for biological treatment of industrial process brines contaminated with aromatics. Journal of Industrial Microbiology and Biotechnology, 2021.

https://doi.org/10.1093/jimb/kuab015  pdf

Novak K., Neuendorf C. S., Kofler I., Kieberger N., Klamt S., Pflügl S. Blending industrial blast furnace gas with H2 enables Acetobacterium woodii to efficiently co-utilize CO, CO2 and H2. Bioresource Technology, 2021, 323, 124573.

https://doi.org/10.1016/j.biortech.2020.124573  pdf

2020

Novak K., Kutscha R., Pflügl S. Microbial upgrading of acetate into 2,3-butanediol and acetoin by E. coli W. Biotechnology for Biofuels, 2020, 13(1), 177.

https://doi.org/10.1186/s13068-020-01816-7  pdf

Novak K., Baar J., Freitag P., Pflügl S. Metabolic engineering of Escherichia coli W for isobutanol production on chemically defined medium and cheese whey as alternative raw material. Journal of Industrial Microbiology and Biotechnology, 47(12), pp. 1117–1132.

https://doi.org/10.1007/s10295-020-02319-y  pdf

Kutscha R., Pflügl S. Microbial upgrading of acetate into value-added products—examining microbial diversity, bioenergetic constraints and metabolic engineering approaches. International Journal of Molecular Sciences, 2020, 21(22), pp. 1–30, 8777.

https://doi.org/10.3390/ijms21228777  pdf

Vees C. A., Neuendorf C. S., Pflügl S. Towards continuous industrial bioprocessing with solventogenic and acetogenic clostridia: challenges, progress and perspectives. Journal of Industrial Microbiology and Biotechnology, 2020, 47(9-10), pp. 753–787.

https://doi.org/10.1007/s10295-020-02296-2  pdf

Erian A. M., Freitag P., Gibisch M., Pflügl S. High rate 2,3-butanediol production with Vibrio natriegens. Bioresource Technology Reports, 2020.

https://doi.org/10.1016/j.biteb.2020.100408  pdf

Vees C. A., Veiter C., Sax F., Herwig C., Pflügl S. A robust flow cytometry-based biomass monitoring tool enables rapid at-line characterization of S. cerevisiae physiology during continuous bioprocessing of spent sulfite liquor. Analytical and Bioanalytical Chemistry, 2020.

https://doi.org/10.1007/s00216-020-02423-z  pdf

2019

Mainka T., Mahler N., Herwig C. Pflügl S. Soft Sensor-Based Monitoring and Efficient Control Strategies of Biomass Concentration for Continuous Cultures of Haloferax mediterranei and Their Application to an Industrial Production Chain. Microorganisms, 2019.

https://doi.org/10.3390/microorganisms7120648  pdf

2018

Erian A. M., Gibisch M., Pflügl S. Engineered E. coli W enables efficient 2,3-butanediol production from glucose and sugar beet molasses using defined minimal medium as eco-nomic basis. Microbial Cell Factories, 2018.

https://doi.org/10.1186/s12934-018-1038-0  pdf

Novak K., Pflügl S. Towards biobased industry: Acetate as a promising feedstock to enhance the potential of microbial cell factories. FEMS Microbiology Letters, 2018.

https://doi.org/10.1093/femsle/fny226  pdf

Novak K., Flöckner L., Erian A. M., Freitag P., Herwig C., Pflügl S. Characterizing the effect of expression of an acetyl-CoA synthetase insensitive to acetylation on co-utilization of glucose and acetate in batch and continuous cultures of E. coli W. Microbial Cell Factories, 2018. 

https://doi.org/10.1186/s12934-018-0955-2  pdf

Kamravamanesh D., Kovacs T., Pflügl S., Druzhinina I., Kroll P., Lackner M., Herwig C. Increased poly-B-hydroxybutyrate production from carbon dioxide in randomly mutated cells of cyanobacterial strain Synechocystis sp. PCC 6714: Mutant generation and Characterization. Bioresource Technology, 2018.

https://doi.org/10.1016/j.biortech.2018.06.057  pdf

Mahler N., Tschirren S., Pflügl S., Herwig C. Optimized bioreactor setup for scale-up studies of extreme halophilic cultures. Biochemical Engineering Journal, 2018. 130: p. 39-46.

https://doi.org/10.1016/j.bej.2017.11.006  pdf

2012-2017

Kamravamanesh D., Pflügl S., Nischkauer W., Limbeck A., Lackner M., Herwig C. Photosynthetic poly-β-hydroxybutyrate accumulation in unicellular cyanobacterium Synechocystis sp. PCC 6714. AMB Express, 2017, 7(1).

https://doi.org/10.1186/s13568-017-0443-9  pdf

Nocon J., Steiger M. G., Pfeffer M., Sohn S. B., Kim T. Y., Rußmayer H., Pflügl S., Haberhauer-Troyer C., Ortmayr K., Koellensperger G., Gasser G., Lee S. Y., Mattanovich D. Metabolic model-based prediction of engineering targets for increased production of heterologous proteins. New Biotechnology, 2014.

https://doi.org/10.1016/j.nbt.2014.05.947  

Nocon J., Steiger M. G., Pfeffer M., Sohn S. B., Kim T. Y., Maurer M., Rußmayer H., Pflügl S., Ask, M., Haberhauer-Troyer C., Ortmayr K., Hann S., Koellensperger G., Gasser G., Lee S. Y., Mattanovich D. Model based engineering of Pichia pastoris central metabolism enhances recombinant protein production. Metabolic Engineering, 2014, 24, pp. 129-138.

https://doi.org/10.1016/j.ymben.2014.05.011  pdf

Pflügl S., Marx H., Mattanovich D., Sauer M. Heading for an economic industrial upgrading of crude glycerol from biodiesel production to 1,3-propanediol by Lactobacillus diolivorans. Bioresource Technology, 2013, 152, pp. 499-504.

https://doi.org/10.1016/j.biortech.2013.11.041  pdf

Dragosits M., Pflügl S., Kurz S., Razzazi-Fazelli E., Wilson I. B. H., Rendic D. Recombinant Aspergillus ß-galactosidases as a robust glycomic and biotechnological tool, Applied Microbiology and Biotechnology, 2014, 98 (8), pp. 3553-67.

https://doi.org/10.1007/s00253-013-5192-3  pdf

Pflügl S., Marx H., Mattanovich D., Sauer M. Genetic engineering of Lactobacillus diolivorans. FEMS Microbiology Letters, 2013, 344 (2), pp. 152-158.

https://doi.org/10.1111/1574-6968.12168  pdf

Pflügl S., Marx H., Mattanovich D., Sauer M. 1,3-Propanediol production from glycerol with Lactobacillus diolivorans. Bioresource Technology, 2012, 119, pp. 133-40.

https://doi.org/10.1016/j.biortech.2012.05.121  pdf