Institut für Verfahrenstechnik, Umwelttechnik und Techn. Biowissenschaften
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Equipment

 

Upstream processing (USP)

  • Screening in 96 well plates (Tecan)

  • Multitron shakers for (aerobic/anaerobic) screening experiments in shakeflasks
  • Multiple reactor designs from 250 mL up to 30 L working scale for aerobic and anaerobic cultivation conditions
  • 3 x 4 compartment bioreactor systems (250 mL, 2 L & 2.5 L) for parallel processes

 

Downstream processing (DSP)

  • Centrifuges

  • Tangential flow filtration (TFF)
  • Preparative Chromatography (ÄKTA pure)

  • Refolding reactor
  • Spray dryer & Freeze-dryer
  • Nanoassembler

 

Analytics

  • PAT tools (Redox, pO2, pH) IR (FTIR near-infrared probe)
  • FCM (Cytoboy, Cube8)

  • HPLC (7 devices) equipped with UV, RI detectors, CAD
  • IC
  • Photometric and fluorescens based methods (spectrophotometer  + Tecan plate reader)
  • Centrifuges & oven for controlled gravimetric assays
  • Novocontrol

 

Organisms

Cultivation of diverse organisms and strains:

  • Yeasts
  • Bacteria
  • Microalgae and Cyanobacteria
  • Archaea
  • Filamentous fungi
  • Bacillus

 

Methods

We are specialized in strain engineering, USP (screening to optimization) and DSP (capture to product formulation):

  • Plasmid and Gene design
  • Protein engineering
  • Strain engineering
  • Recombinant protein production
  • DSP
  • Refolding
  • Data analysis and modeling
  • Analytical methods development
  • 3D printing
  • Liposome formulation
  • Lipid analysis