Institute of Chemical Engineering
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Efficient Protein Production in Trichoderma reesei

Trichoderma reesei is an important producer of industrial applied enzymes. Conventional strain improvement by mutagenesis and selection has led to strains that secrete more than 100 g/l of homologous proteins. The reasons for this protein hyperproduction are largely unknown and production levels of heterologous proteins are usually much lower. In addition these highly mutated strains have accumulated numerous negative mutations affecting their overall fitness. To design new recombinant strains which exceed the current production levels for proteins and show a better overall performance, different industrially relevant strain lines will be compared to their ancestors by state of the art systems biological approaches including genomics, transcriptomics and proteomics.

In combination with advanced genetic engineering techniques we will design yield improved strains for efficient protein production.