Institute of Chemical Engineering
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Analyzing CFD Simulation Outputs on Physiologic Effects And Process Performance

Problem Statement


  • Scale up of processes is a difficult task due to inhomogeneities which are present in large scale reactors.
  • Cells undergo dynamic gradients in large scale, leading to different metabolic responses than in small scale.
  • Process performance in large scale is therefore different than in small scale.
  • Process development strategies need to take those scale up effects into account and need to anticipate and ideally compensate those effects.


  • Derive a methodological workflow to quickly assess if a CFD inhomogeneity pattern actually has an impact on physiology and process performance
  • Provide novel Feeding strategies to compensate scale up effects 

Unique position at VUT

  • Pilot scale reactors of 60 L and 20 L are available at Vienna University of Technology (VUT) for which CFD simulations exist an can be used as scale down reactors.
  • Those reactors can be run at suboptimal conditions to mimic gradients as extracted from CFD simulations of large scale reactors.
  • VUT as distinct knowledge in physiological feeding strategies, such as constant or dynamic specific uptake rates.



Research hypothesis

  • With the scale down reactors with existing CFD simulations, effects of inhomogeneities in large scale reactors can be quickly assessed.
  • Novel physiological feeding strategies can overcome impacts of inhomogeneities and therefore allow compensation scale up effects.



Univ.Prof. Dipl.-Ing. Dr.techn. Christoph Herwig


Danish research consortium

Consortium Lead, DTU, Denmark, Prof. Krist Gernaey

Dr. Jens Fricke