Institute of Chemical Engineering
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Continuous biomanufacturing

Most industrial processes using microbial hosts are carried out in fed-batch mode. However, recent trends show that the biotech industry is moving toward time-independent processing, trying to improve the space-time yield. In the 1950s, the term "chemostat" was introduced first-time by Novick and Szilard, who followed up on the previous work performed by Monod. Chemostat processing resulted in a major hype 10 years after its official introduction. However, enthusiasm decreased as experiments suffered from genetic instabilities and physiology issues.Within this research topic we focus on new applications, trying to enable continuous bioprocessing. Thereby we predominantly investigate parallelization, cascaded continuous cultivation and population monitoring.

 

Current projects:

 

Open Positions

BSc/MSc students and interns are always welcome!